Postdoctoral Research Fellow – DNA/Aptamer Chemist

at University of British Columbia, Vancouver, Canada

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Salary

Not given in the advert

Closing date

Open until filled

Start

Not given in the advert

Type of post

Research

First seen

30 October 2026, on a public job listing

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The advert

Job Title

Postdoctoral Research Fellow - DNA/Aptamer Chemist

Job Category

Faculty Non Bargaining

Job Family Group

Academic

Department

Research | Perrin Lab | Department of Chemistry | Faculty of Science (David Perrin)

Job End Date

October 31, 2027

Posting End Date

November 6, 2026

Note: Applications will be accepted until 11:59 PM on the Posting End Date.

The expected pay range for this position is $55,000 - $65,000/annually.

University of British Columbia, Perrin Laboratory (https://perrin.chem.ubc.ca/)

We are seeking a highly motivated DNA/Aptamer Chemist to join a multidisciplinary research team developing nucleic acid-based targeting agents to treat prostate cancer. The successful candidate will focus on the design, synthesis, modification and biophysical characterization of DNA aptamers. This position would be particularly well suited to a chemist or chemical biologist interested in applying nucleic acid chemistry to translational cancer research.

Responsibilities

● Design and synthesis of DNA aptamers and modified oligonucleotides.

● Solid-phase oligonucleotide synthesis, purification and quality control.

● Chemical modification and functionalization of DNA, including incorporation of linkers, fluorophores, chelators and other functional groups.

● Purification and analytical characterization using HPLC, LC-MS and related approaches.

● Systematic structure-function studies using nucleotide substitutions, truncations and chemical modifications.

● Development of aptamers with improved affinity, selectivity and stability.

● Quantitative characterization of aptamer-protein interactions using biochemical and biophysical approaches.

● Conjugation of aptamers to imaging or therapeutic payloads.

● Collaboration with protein biochemists, molecular biologists, structural biologists and imaging scientists.

Qualifications

Candidates should have a PhD in chemistry, chemical biology, biochemistry or a closely related field. Candidates must have demonstrated experience i.e. published work in several of the following areas:

● Oligonucleotide/DNA chemistry

● Solid-phase oligonucleotide synthesis

● Nucleic acid modification and conjugation

● Aptamer development or SELEX

● Protein-ligand binding assays

● Bioanalytic skill including techniques such as SPR, BLI, MST, ITC, HPLC and LC-MS

● Structure-function analysis of nucleic acids

● Nucleic acid-protein interactions

Work Location:

· The primary work location is the UBC Vancouver Campus

Application Process:

· Seeking full-time PDF for 12 months with the possibility of extension.

About University of British Columbia

Type

University

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